Dacarbazine for injection usp is a white to an ivory colored solid which is light sensitive. Pharmaceutical form powder for injection dacarbazine is a colourless to pale yellow solid, sensitive to light. Dacarbazine may cause potentially fatal allergic reactions or other serious problems in some people. Reconstitute with sterile water for injection, ns, or d5w to a concentration of 10 mgml. This medication is classified as an alkylating agent. Dec 31, 2019 dacarbazine for injection, usp is reconstituted and administered intravenously ph 34.
You can also use the context menu to add a blank page in between to pages. This is not a complete list of side effects and others may occur. Dacarbazine may also cause rare but serious liver problems. Endpt durable response rate % pts w cr or pr maintained 6mo.
Side effects of dticdome dacarbazine, warnings, uses. Dacarbazine for injection, usp is an anticancer agent. The nurse or doctor who gives this medication must be carefully trained. Dacarbazine metastatic malignant melanoma nhs wales. Nov 05, 2008 our dticdome dacarbazine side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Chemically, dacarbazine is 53,3dimethyl1triazeno imidazole4carboxamide with the following structural formula. Dacarbazine has been shown to be mutagenic, teratogenic and carcinogenic in animals. Dacarbazine may cause fetal harm when used during pregnancy, based on its mechanism of action and data from animal studies. When dacarbazine is used to treat melanoma, it may be injected once a day for 10 days in a row every 4 weeks or it may be injected. Dacarbazine is an anticancer antineoplastic or cytotoxic chemotherapy drug. Special pediatric considerations are noted when applicable, otherwise adult provisions apply. Dacarbazine is approved to be used alone or with other drugs to treat hodgkin lymphoma in patients whose disease has not gotten better with other chemotherapy melanoma that has metastasized spread to other parts of the body dacarbazine is also being studied in the treatment of other. It must be assumed that an increased risk for teratogenic effects exists in humans. Goodrx s cash prices are based on multiple sources, including published price lists, purchases, claims records, and data provided by pharmacies.
Dacarbazine side effects, dosage, interactions drugs. The pdf file should be the first option within the insert dialog window. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for dilantin phenytoin. In the page thumbnail view, rightclick the page where you want to insert a blank page. Skin damage by dacarbazine can lead to deep necrosis requiring surgical debridement, skin grafting, and even amputation. Open powerpoint and display the slide where you want to insert the pdf graphic. Details concerning dosing in combination regimens should also. Information for the patient dacarbazine medac 200 mg powder for solution for injectioninfusion dacarbazine read all of this leaflet carefully before you start using this medicine because it contains important information for you. An alternate recommended dosage is 200 to 250 mgm2 of body. Besides unchanged dacarbazine, 5aminoimidazole4carboxamide aic is a major metabolite of dacarbazine excreted in the urine. Bioequivalence has been established only when temodar for injection was given over 90 minutes see clinical pharmacology 12.
Dacarbazine is available as an injectable solution in 100, 200, and 500mg vials fda 2009. Therefore dacarbazine medac is contraindicated during pregnancy see section 4. Insert pdf file content into a powerpoint presentation. Doxorubicin and dacarbazine ad regimen for soft tissue. Since dacarbazine is light sensitive, the solution should be protected from light immediately following preparation. Each 20 ml vial contains 200 mg of dacarbazine active ingredient.
Hodgkins disease metastatic melanoma metastatic melanoma soft tissue sarcoma available dosage form in the hospital. Medlineplus information on dacarbazine a lay language summary of important information about this drug that may include the following. Request permission export citation add to favorites. Combine or merge files into a single pdf, adobe acrobat dc.
The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. Dailymed dacarbazine injection, powder, for solution. Women of childbearing potential have to use effective contraception during treatment. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication. Reevaluating the role of dacarbazine in metastatic melanoma. F or greater or for any serious febrile drug reaction and. Dacarbazine medac 200 mg powder for solution for injectioninfusion. Emcyt capsules are white and opaque, each containing estramustine phosphate sodium as the disodium salt monohydrate equivalent to 140 mg estramustine phosphate, for oral administration. Dacarbazine for injection, usp is reconstituted and administered intravenously ph 34. In powerpoint, select the slide that you want to add the file to, and then select insert object. Insert pdf file content into a powerpoint presentation powerpoint. The dosage of dtic was 1,000 mgm2 in 33 dogs and 800 mgm2 in 7 dogs.
Medicinal forms there can be variation in the licensing. Known hypersensitivity to any temodar component or to dacarbazine dtic. Geriatric patients and women have a higher risk of developing. Dacarbazine is used to treat skin cancer malignant melanoma and hodgkins disease. Dacarbazine metastatic malignant melanoma background. Dacarbazine was teratogenic in rats at doses 20times the daily human dose on day 12 of gestation. Dacarbazine fda prescribing information, side effects and uses.
Clinical pharmacology after intravenous administration of dacarbazine for injection, the volume of distribution exceeds total body water content suggesting localization in some body tissue, probably the liver. Hepatotoxic drugs and alcohol should be avoided during chemotherapy dacarbazine may influence the ability to drive or operate machines because of its central nervous side effects or because of nausea and vomiting. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for dilantin phenytoin skip to. Dacarbazine can be dosed in dogs at 200 mgm 2 as a slow iv bolus given once daily for 5 days, or once as a slow iv infusion over 2 to 8 hours at mgm 2 every 3 weeks. Emcyt estramustine phosphate sodium capsules description. Each 20 ml vial contains 200 mg of dacarbazine, usp active ingredient.
Dacarbazine alkylates and crosslinks dna during all phases of the cell cycle, resulting in disruption of dna function, cell cycle arrest, and apoptosis. This prescription drug comes as an injection that is given into a vein intravenously, or by iv. Our dticdome dacarbazine side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. The dose that is used may depend on a number of things, including what the medicine is being used for, the patients weight, and whether or not other medicines are also being taken. Cancer studies in experimental animals dacarbazine caused tumors in two rodent species, at several different tissue sites, and by two different routes of exposure. Our discount and coupon prices are based on contracts between a pharmacy or pharmacy purchasing group and a pharmacy benefit manager pbm, who provides. Insert pdf content into your presentation either as a picture that shows on your slide, or as a document that you can open during your slide show. If the medication escapes from the vein it can cause tissue damage. The product catalog provides you with a full listing of tevas brand and generic product lines. A randomized phase 2 study of etaracizumab, a monoclonal. You can also add a blank page to your pdf document by. Call your doctor for medical advice about side effects. Choose tools organize pages to get the page thumbnail view.
Dacarbazine for injection bp is a potent drug and should be used only by. Click the image and it will be inserted into the slide. Dailymed dacarbazine dacarbazine injection, powder, for. Antineoplastic agent, alkylating agent triazene indications. Jun 10, 2019 dacarbazine pharmacokinetics absorption bioavailability. Dacarbazine dacarbazine dose, indications, adverse. Dacarbazine is the standard 1 st line treatment for patients with malignant metastatic melanoma. Oct 01, 2019 dacarbazine is subject to renal tubular secretion rather than glomerular filtration. Dacarbazine for injection, usp is a colorless to an ivory colored solid which is light sensitive. Dacarbazine is an antineoplastic agent and alkylating agent that is fda approved for the treatment of metastatic malignant melanoma and also indicated for hodgkins disease as a secondaryline therapy when used in combination with other effective agents there is a black box warning for this drug as shown here. Dacarbazine dacarbazine dose, indications, adverse effects.
Older adults, the very young, comatose, and debilitated patients are especially at risk. Dacarbazine 100mg, 200mg, 500mg, mg summary of product. Dacarbazine is subject to renal tubular secretion rather than glomerular filtration. Sign in or purchase a subscription to access this content. Dacarbazine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Severe local tissue necrosis will occur if there is extravasation during administration. In the insert object box, select create from file, and then enter the pdf file location. This prescription drug comes as an injection that is given into a. Greater than 3 to 5 times the uln, reduce dose 75%. An irritant is a chemical that can cause inflammation of the vein through which it is given. For hodgkins it is often used together with vinblastine, bleomycin, and doxorubicin. Dilute with 250 ml to 1,000 ml ns, d5w, or a salinedextrose solution. Dacarbazine injection comes as a powder to be mixed with liquid to be injected intravenously into a vein over 1 minute or infused intravenously over 15 to 30 minutes by a doctor or nurse in a medical facility. Definition from the nci drug dictionary detailed scientific definition and other names for this drug. Dacarbazine is given into a vein intravenously, iv. Nov 01, 2014 dacarbazine for injection usp is a white to an ivory colored solid which is light sensitive. Doxorubicin and dacarbazine ad regimen for soft tissue sarcomas. Dosage of temodar must be adjusted according tonadir neutrophil and platelet counts in the previous cycle and the neutrophil and platelet counts at the time of initiating the next cycle.
In patients treated with tafinlar, the median time to initial onset of fever any 60 severity was 11 days range. Dacarbazine is an anticancer agent designated chemically. Other risk factors include establishing an iv line in a vein previously punctured several times and the use of nonplastic catheters. The catalog displays all strengths and sizes along with the description, imprint code, ndc and photo for each product. Dacarbazine for injection usp is reconstituted and administered intravenously ph 3. Volume of distribution exceeds total body water content, suggesting localization in a body tissue, probably the liver. Dacarbazine is a structural analogue of imidazole carboxamide, a purine precursor. Dacarbazine for injection is reconstituted and administered intravenously ph 34.
This makes the pdf file part of the presentation file. Dacarbazine is also used in combination with other medications to treat hodgkins lymphoma hodgkins disease. Comparison of the efficacy of two different dosage dacarbazine regimens and two regimens without dacarbazine in metastatic melanoma. This emedtv page covers some warnings on how to safely use dacarbazine, with precautions for people with who may have a high risk for complications. Highlights of prescribing information pneumonia pcp pcp. Dacarbazine for injection is a colorless to an ivory colored solid which is light sensitive. It must neverbe given by the intramuscular or subcutaneous route. Each vial also contains anhydrous citric acid and mannitol.
Dacarbazine is an approved drug for use with soft tissue sarcomas. Dacarbazine is also being studied in the treatment of other types of cancer. Metastatic malignant melanoma life expectancy 12 weeks ecog ps 02 pretreatment assessment. Dacarbazine is a triazene derivative with antineoplastic activity. Dacarbazine interferes with the growth of cancer cells, which are eventually destroyed. For more detail, see how this drug works section below.
Dacarbazine dosage the recommended dacarbazine dosage will be different for each person, depending on his or her weight, the reason the medicine is being used, and a number of other factors. Open your powerpoint presentation on the page you want to insert the pdf within. Dacarbazine belongs to the group of medicines called alkylating agents. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. It is used to treat cancer of the lymph system and malignant melanoma a type of skin cancer. Gmcsf attracts dendritic cells, which present tumor ags to t cells programming them to destroy cancer cells throughout the body. Dosage may be reduced andor delayed in patients with bone marrow depression due to cytotoxicradiation therapy. Dosing the dose of dacarbazine will be different for different patients. It may also be used to treat other kinds of cancer, as determined by your doctor. Dec 01, 2016 dacarbazine belongs to the group of medicines called alkylating agents. In the insert pages dialog box, specify the location where you want to add the blank page. Dacarbazine is used for metastatic malignant melanoma, hodgkins disease, soft tissue sarcomas. Dacarbazine by injection national library of medicine. A phase iii randomized trial of dacarbazine and carboplatin with and.
However, no data are available on the use of dtic as a single agent in the. Nov 09, 2018 dacarbazine is a cancer medication that interferes with the growth and spread of cancer cells in the body. Dacarbazine fda prescribing information, side effects. Dacarbazine is used to treat melanoma a type of skin cancer that has spread to other parts of your body. Each vial contains 200 mg of dacarbazine the active ingredient, citric acid monohydrate and mannitol.